Publications
2024
Shah K, He S, Turner DJ, Corbo J, Rebbani K, Dominguez D, Bateman JM, Cheloufi S, Igreja C, Valkov E*, Murn J*. (2024) Regulation by the RNA-binding protein Unkempt at its effector interface. Nat Commun. Apr 11;15:3159; doi: https://doi.org/10.1038/s41467-024-47449-4 | PDF *Co-corresponding authors.
2023
Shah K, He S, Turner DJ, Corbo J, Rebbani K, Bateman JM, Cheloufi S, Igreja C, Valkov E*, Murn J*. (2023) A paradigm for regulation at the effector interface with RNA-binding proteins. bioRxiv. Sep 21; doi: https://doi.org/10.1101/2023.09.20.558714 | PDF *Co-corresponding authors.
He S, Valkov E, Cheloufi1 S, Murn J. (2023) The nexus of RNA-binding proteins and their effectors Nat Rev Genet. May;24(5):276-294. doi: 10.1038/s41576-022-00550-0. Pubmed | PDF
Baskaran P, Mihaylov SR, Vinsland E, Shah K, Granat L, Ultanir SK, Tee AR, Murn J*, Bateman JM*. (2022) Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis. J Biol Chem. Dec 9:102788. doi: 10.1016/j.jbc.2022.102788. Pubmed | PDF *Co-corresponding authors.
2022
Franklin R, Guo Y, He S, Ji F, Chen M, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco A, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev R, Murn J*, Volk A*, Cheloufi1 S.* (2022) Regulation of chromatin accessibility by the Histone Chaperone CAF-1 sustains lineage fidelity. Nat Commun. Apr 29;13(1):2350. Pubmed | PDF *Co-corresponding authors.
2021
Vinsland E, Baskaran P, Mihaylov SR, Hobbs C, Wood H, Bouybayoune I, Shah K, Houart C, Tee AR, Murn J, Fernandes C, Bateman JM. (2021) The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Sci Rep. Aug;11(1):18299. Pubmed | PDF
Shi J, Zhang Y, Tan D, Zhang X, Yan M, Zhang Y, Franklin R, Shahbazi M, Mackinlay K, Liu S, Kuhle B, James ER, Zhang L, Qu Y, Zhai Q, Zhao W, Zhao L, Zhou C, Gu W, Murn J, Guo J, Carrell DT, Wang Y, Chen X, Cairns BR, Yang W, Schimmel P, Zernicka-Goetz M, Cheloufi S, Zhang Y, Zhou T, Chen Q. (2021) PANDORA-seq expands the functional small RNA repertoire by overcoming RNA modifications. Nat Cell Biol. Apr;23(4):424-436. Pubmed | PDF
Franklin R, Murn J*, Cheloufi S*. (2021) Cell Fate Decisions in the Wake of Histone H3 Deposition. Front Cell Dev Biol. Apr 20;9:654915. Pubmed | PDF *Co-corresponding authors.
2020
Guo Y, Ji F, Murn J, Frankhouser D, Blanco MA, Chiem C, Jang M, Sadreyev R, Rockne RC, Sykes DB, Hochedlinger K, Cheloufi S. (2020) The Histone Chaperone CAF-1 Sustains Myeloid Lineage Identity bioRxiv. Mar 20; doi: https://doi.org/10.1101/2020.10.22.350447 | PDF
2018
Iyer EPR, Punthambaker S, Liu S, Jindal K, Farrell M, Murn J, Ferrante T, Rudnicki S, Kohman RE, Wassie AT, Goodwin D, Chen F, Alon S, Sinha A, Milanova D, Aron L, Camplisson C, Skrynnyk A, Reginato PL, Conway N, Aach J, Yankner B, Boyden ES, Church GM. (2018) Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in-situ analyses. bioRxiv. Mar 20; doi: https://doi.org/10.1101/281121 | PDF
2017
Murn J, Shi Y. (2017) The winding path of protein methylation research: milestones and new frontiers. Nat Rev Mol Cell Biol. Aug;18(8):517-527. Pubmed | PDF
PMID: 28512349
2016
Murn J*, Teplova M*, Zarnack K, Patel DJ, Shi Y. (2016) Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Nat Struct Mol Biol. Jan;23(1):16-23. *Co-first authors. Pubmed | PDF (Supplemental Information)
PMID: 26641712
2015
Cheloufi S, Elling U, Hopfgartner B, Jung Y, Murn J, Badeaux A, Blanco A, Ang CE, Tennen D, Ferrari F, Wesche D, Abazova N, Hogue M, Tasdemir N, Rathert P, Vidal S, Fellner M, Wenzel D, Zinner M, Stadtfeld M, Almouzni G, Lowe SW, Rinn J, Wernig M, Shi Y, Park P, Penninger JM, Zuber J, Hochedlinger K. (2015) The histone chaperone CAF-1 safeguards somatic cell identity. Nature. Dec 10;528(7581):218-24. Pubmed | PDF
PMID: 26659182
Murn J*, Zarnack K, Yang YJ, Durak O, Murphy EA, Cheloufi S, Gonzalez DM, Teplova M, Curk T, Zuber J, Patel DJ, Ule J, Luscombe NM, Tsai LH, Walsh CA, Shi Y*. (2015) Control of a neuronal morphology program by an RNA-binding zinc finger protein Unkempt. Genes Dev. Mar 1;29(5):501-12. *Co-corresponding authors. Pubmed | PDF (Supplemental Information)
PMID: 25737280
Laurent B, Ruiti L, Murn J, Hempel K, Ferrao R, Xiang Y, Liu S, Garcia BA, Wu H, Wu F, Steen H, Shi Y. (2015) The LSD1/KDM1A neuro-specific isoform regulates neuronal differentiation through H3K9 demethylation. Mol Cell. Mar 19;57(6):957-70. Pubmed | PDF
PMID: 25684206
2014
Busskamp V, Lewis NE, Guye P, Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J, Li Y, Li S, Stadler M, Weiss R, Church GM. Rapid neurogenesis through transcriptional activation in human stem cells. Mol Syst Biol. Nov 17;10:760. Pubmed | PDF
PMID: 25403753
Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco A, Chen S, Stützer A, Armache KJ, Simon MD, Xu C, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Min J, Kingston RE, Fischle W, Warren ST, Page DC, Shi Y. (2014) A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell. May 8;157(4):869-81. Pubmed | PDF
PMID: 24813610
2012
Yang YJ, Baltus AE, Mathew RS, Murphy EA, Evrony GD, Gonzalez DM, Wang EP, Marshall-Walker CA, Barry BJ, Murn J, Tatarakis A, Mahajan MA, Samuels HH, Shi Y, Golden JA, Mahajnah M, Shenhav R, Walsh CA. (2012) Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. Cell. Nov 21;151(5):1097-112. Pubmed | PDF
PMID: 23178126
2011
Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, Carver BS, Trotman LC. (2011) Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. Aug 16;20(2):173-86. Pubmed | PDF
PMID: 21840483
2009
Murn, J, Mlinaric-Rascan, I, Vaigot, P, Frouin, V, Gidrol, X. (2009) A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering. BMC Genomics. Jul 17;10:323. Pubmed | PDF
PMID: 19607732
2008
Murn, J, Tendil, S, Wu, N, Alibert, O & Gidrol, X. Prostaglandin E2 regulates B-cell proliferation through a candidate tumor suppressor, Ptger4. (2008) J Exp Med. Dec 22;205(13):3091-103. Pubmed | PDF
PMID: 19075289
2006
Milek, M, Murn J, Jaksic, Z, Lukac Bajalo, J, Jazbec, J & Mlinaric-Rascan, I. (2006) Thiopurine S-methyltransferase pharmacogenetics: genotype to phenotype correlation in the Slovenian population. Pharmacology. 77(3):105-14. Pubmed | PDF
PMID: 16691038
2005
Anderluh, M, Cesar, J, Stefanic, P, Kikelj, D, Janes, D, Murn J, Nadrah, K, Tominc, M, Addicks, E, Giannis, A, Stegnar, M & Dolenc, M.S. (2005) Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study. Eur J Med Chem. Jan;40(1):25-49. Pubmed | PDF
PMID: 15642407
2004
Murn, J, Urleb, U & Mlinaric-Rascan, I. (2004) Internucleosomal DNA cleavage in apoptotic WEHI 231 cells is mediated by a chymotrypsin-like protease. Genes Cells 9. Nov;9(11):1103-11. Pubmed | PDF
PMID: 15507121